|
Heart failure
|
0.230 |
Therapeutic
|
disease |
RGD |
In systolic HF, the downregulation of SERCA2a (sarcoplasmic-endoplasmic reticulum calcium ATPase), along with an increased BNIP3 expression, further worsen myocardial diastolic and systolic function and contribute to the major remodeling seen in systolic HF as compared with diastolic HF with normal SERCA2a expression.
|
23508759 |
2013 |
|
Congestive heart failure
|
0.230 |
Therapeutic
|
disease |
RGD |
In systolic HF, the downregulation of SERCA2a (sarcoplasmic-endoplasmic reticulum calcium ATPase), along with an increased BNIP3 expression, further worsen myocardial diastolic and systolic function and contribute to the major remodeling seen in systolic HF as compared with diastolic HF with normal SERCA2a expression.
|
23508759 |
2013 |
|
Chronic Obstructive Airway Disease
|
0.210 |
Therapeutic
|
disease |
RGD |
Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease.
|
25888379 |
2015 |
|
Myocardial Infarction
|
0.210 |
Biomarker
|
disease |
RGD |
The key findings of the present study were: a) upregulation of autophagy-related genes (GABARAPL1, ATG7, BNIP3, CTSL1 and LAMP2) was observed only in plantaris while muscle atrophy was observed in both soleus and plantaris muscles, and b) Cathepsin L activity, Bnip3 and Fis1 protein levels, and levels of lipid hydroperoxides were increased specifically in plantaris muscle of MI rats.
|
24427319 |
2014 |
|
Retinal Detachment
|
0.210 |
Biomarker
|
disease |
RGD |
Hypoxia inducible factor 1α contributes to regulation of autophagy in retinal detachment.
|
26093278 |
2015 |
|
Transient Ischemic Attack
|
0.200 |
Biomarker
|
disease |
RGD |
Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus.
|
14972662 |
2004 |
|
Hemorrhage
|
0.200 |
Biomarker
|
phenotype |
RGD |
Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injury.
|
21193900 |
2011 |
|
Kidney Failure, Chronic
|
0.200 |
Biomarker
|
disease |
RGD |
Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach.
|
24090408 |
2013 |
|
Myocardial Reperfusion Injury
|
0.200 |
Therapeutic
|
phenotype |
RGD |
Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy.
|
16645637 |
2007 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
RGD |
Pro-apoptotic Bcl2 family members, Bcl-2/adenovirus E1B 19 kDa interacting protein (BNIP3) and Bad levels, were significantly increased in obese rat hearts, whereas anti-apoptotic Bcl2 family member, Bcl2 level, was significantly decreased.
|
18070754 |
2007 |
|
Subarachnoid Hemorrhage
|
0.200 |
Therapeutic
|
disease |
RGD |
Inhibiting HIF-1α by 2ME2 ameliorates early brain injury after experimental subarachnoid hemorrhage in rats.
|
23850688 |
2013 |
|
Hyperoxia
|
0.200 |
Biomarker
|
phenotype |
RGD |
Gene expression microarray analysis of early oxygen-induced retinopathy in the rat.
|
20157446 |
2009 |
|
Infarction, Middle Cerebral Artery
|
0.200 |
Biomarker
|
disease |
RGD |
BNIP3 upregulation and EndoG translocation in delayed neuronal death in stroke and in hypoxia.
|
17379825 |
2007 |
|
Chronic kidney disease stage 5
|
0.200 |
Biomarker
|
disease |
RGD |
Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach.
|
24090408 |
2013 |
|
Liver carcinoma
|
0.070 |
AlteredExpression
|
disease |
LHGDN |
We found that the gene expression of BNIP3 was up-regulated while ZK1, RAD23B, and HSPD1 were down-regulated during early apoptosis of the hepatoma cell mediated by PRE.
|
12215374 |
2002 |
|
Pancreatic Neoplasm
|
0.040 |
Biomarker
|
disease |
LHGDN |
Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer.
|
15289340 |
2004 |
|
Pancreatic Neoplasm
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis.
|
17729412 |
2007 |
|
Pancreatic Neoplasm
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer.
|
17638890 |
2007 |
|
Pancreatic Neoplasm
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis.
|
15856026 |
2005 |
|
Anoxia
|
0.030 |
AlteredExpression
|
phenotype |
LHGDN |
Hypoxia and expression of the proapoptotic regulator BNIP3 in cervical cancer.
|
16803523 |
2007 |
|
Anoxia
|
0.030 |
Biomarker
|
phenotype |
LHGDN |
Taken together, these results suggest that prolonged hypoxia induces autophagic cell death in apoptosis-competent cells, through a mechanism involving BNIP3.
|
18059169 |
2008 |
|
Anoxia
|
0.030 |
AlteredExpression
|
phenotype |
LHGDN |
Since an association between BNIP3 and AR and the HIFs was observed, the influence of hypoxia, dihydrotestosterone and the AR blocker, Casodex, was also investigated in prostate cell lines.
|
18163427 |
2008 |
|
Glioblastoma
|
0.030 |
AlteredExpression
|
disease |
LHGDN |
The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastoma multiforme tumor cell survival under hypoxia.
|
16217754 |
2006 |
|
Mammary Neoplasms
|
0.030 |
AlteredExpression
|
group |
LHGDN |
Up-regulation of BNIP3 expression in DCIS and invasive carcinoma suggests a significant role in breast tumor progression.
|
17255267 |
2007 |
|
Noninfiltrating Intraductal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
Conversely, nuclear BNIP3 expression in DCIS was associated with a 3-fold increase in recurrence and a shorter disease-free survival (P = 0.03).
|
17255267 |
2007 |